The Woodruff School is housed in a multibuilding classroom/research complex. Included in this complex are modern classrooms and seminar conference rooms that serve the entire Institute. The School has many types of specialized instruments and other equipment associated with its laboratories in mechanical engineering for the study of acoustics and dynamics; automation and mechatronics; bioengineering; computer-aided engineering and design; fluid mechanics; heat transfer, combustion, and energy systems; manufacturing; mechanics of materials; MEMS; and tribology. The Nuclear and Radiological Engineering Program has special facilities for the study of computational reactor physics; fast reactors; fusion; medical physics; and radiation detection.

Special facilities in the Woodruff School include laboratories dedicated for undergraduate use; the Integrated Acoustic Laboratory (anechoic chamber); a high-bay area for research and testing; an underwater acoustic tank; a wind tunnel; and a clean room for MEMS fabrication. Laboratories include: Active Control Lab; Active Materials and Devices Lab; Advanced Assembly Process Technology Lab; Advanced Intelligent Mechatronics Research Lab; Biothermal Sciences Lab; Cardiovascular Fluid Mechanics Lab; Cartilage Mechanics and Mechanobiology Lab; Cellular and Molecular Biomechanics Lab; Computational Hydrodynamics and Biofluids Lab; Computer-Aided Simulation of Packaging Reliability, Data Center Thermal Management; Dynamics Properties Research Lab; Engineering Information Systems Lab; Environmentally Conscious Design and Manufacture Lab; Fluid Mechanics Research Lab, Composites Manufacturing Research Lab, Intelligent Machine Dynamics Lab, Mechanical Properties Research Lab, Medical Devices Lab; Microelectronics Thermal Management; Microthermal Systems Lab; Nanoscale Thermal Measurement and Manufacturing; Precision Machining Research Consortium, Rapid Prototyping and Manufacture; Robotics Mechanisms Lab; Systems Realization Lab, Sustainable Thermal Systems Lab, Tribology and Rheology; and the Vascular and Biofluids Lab. Centers include: Center for Polymer Processing; Center for Surface Engineering and Tribology; Composites Education and Research Center; Fluid Power and Motion Control; Georgia Tech/Emory Center for the Engineering of Living Tissues; Technology Center Product Lifecycle Management Center of Excellence; Manufacturing Research Center

The facilities available for the nuclear and radiological engineering and medical physics programs include a radiation control zone, which houses a graphite subcritical assembly, a californium-252 source, and an AmBe source for use in neutron dosimetry studies; numerous high-speed computing clusters; and facilities for analyzing environmental samples by nuclear techniques. Laboratories include: AREVA Radiation Detection Lab; Microchannel Test Facility; Neutron Reference Field Lab; Plasma-facing Components Thermal-hydraulic Test Facility; Southern Nuclear Radiation Physics Lab; and the Thermoluminscent Detector Lab.