The Woodruff School is housed in a multibuilding classroom/research complex. Included in this complex are modern classroom/seminar conference rooms that serve the entire Institute. The School has many types of specialized instruments and other equipment associated with its laboratories in mechanical engineering for the study of acoustics and dynamics; automation and mechatronics; bioengineering; computer-aided engineering and design; fluid mechanics; heat transfer, combustion, and energy systems; manufacturing; mechanics of materials; microelectromechanical systems; and tribology. The Nuclear and Radiological Engineering Program has special facilities for the study of fission, fusion, and medical physics.

Special facilities in the Woodruff School include laboratories dedicated to undergraduate use; the Integrated Acoustic Laboratory (anechoic chamber); a hi-bay area for research and testing; an underwater acoustic tank; a wind tunnel; and a clean room for MEMS fabrication. Laboratories include: Computer-Aided Simulation of Packaging Reliability Lab, Dynamics Properties Research Lab, Fluid Mechanics Research Laboratories, Composites Manufacturing Research Lab, Intelligent Machine Dynamics Laboratory, Mechanical Properties Research Lab, Precision Machining Research Consortium, Systems Realization Laboratory, Sustainable Thermal Systems Laboratory, and the Vascular and Biofluids Laboratory.

The facilities available for the nuclear and radiological engineering and medical physics programs include a radiation control zone, which houses a graphite subcritical assembly, a californium-252 source and an AmBe source for use in neutron dosimetry studies. Other facilities include: numerous high-speed computing clusters, thermal-hydraulic laboratories, a complete nuclear instrumentation laboratory, radiochemical laboratories, and facilities for analyzing environmental samples by nuclear techniques.